Plant Transcription Factor Database
Previous version: v3.0
Nicotiana sylvestris
GRF Family
Species TF ID Description
XP_009767378.1GRF family protein
XP_009771979.1GRF family protein
XP_009781044.1GRF family protein
XP_009783589.1GRF family protein
XP_009784651.1GRF family protein
XP_009784757.1GRF family protein
XP_009790531.1GRF family protein
XP_009790532.1GRF family protein
XP_009790956.1GRF family protein
XP_009791786.1GRF family protein
XP_009791787.1GRF family protein
XP_009794508.1GRF family protein
XP_009794509.1GRF family protein
XP_009794510.1GRF family protein
XP_009797585.1GRF family protein
XP_009797586.1GRF family protein
XP_009797587.1GRF family protein
XP_009797588.1GRF family protein
XP_009797590.1GRF family protein
XP_009797591.1GRF family protein
XP_009800681.1GRF family protein
XP_009800682.1GRF family protein
GRF Family Introduction

Previously, we identified a novel rice gene, GROWTH-REGULATING FACTOR1 (OsGRF1), which encodes a putative transcription factor that appears to play a regulatory role in stem elongation. We now describe the GRF gene family of Arabidopsis thaliana (AtGRF), which comprises nine members. The deduced AtGRF proteins contain the same characteristic regions--the QLQ (Gln, Leu, Gln) and WRC (Trp, Arg, Cys) domains--as do OsGRF1 and related proteins in rice, as well as features indicating a function in transcriptional regulation. Most of the AtGRF genes are strongly expressed in actively growing and developing tissues, such as shoot tips, flower buds, and roots, but weakly in mature stem and leaf tissues. Overexpression of AtGRF1 and AtGRF2 resulted in larger leaves and cotyledons, as well as in delayed bolting of the inflorescence stem when compared to wild-type plants. In contrast, triple insertional null mutants of AtGRF1-AtGRF3 had smaller leaves and cotyledons, whereas single mutants displayed no changes in phenotype and double mutants displayed only minor ones. The alteration of leaf growth in overexpressors and triple mutants was based on an increase or decrease in cell size, respectively. These results indicate that AtGRF proteins play a role in the regulation of cell expansion in leaf and cotyledon tissues.

Kim JH, Choi D, Kende H.
The AtGRF family of putative transcription factors is involved in leaf and cotyledon growth in Arabidopsis.
Plant J. 2003 Oct;36(1):94-104.
PMID: 12974814